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Many health workers at big U.S. hospital chains with vaccine mandates are getting shots.

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Hundreds of sought-after nurses are leaving some U.S. hospitals that have established vaccine requirements for all employees, involving some protests and legal opposition. But most workers, especially at large hospital chains, appear to be complying with the policies.

New York hospitals and nursing homes are grappling with the state’s Monday deadline for workers to have received at least one coronavirus vaccine dose, with thousands of workers remaining unvaccinated and at risk of being fired. Several other states and cities have also imposed mandates for health care workers, with deadlines approaching.

All are also facing a looming federal vaccine mandate for hospital and nursing home staff that President Biden ordered, though its exact scope and timing has yet to be announced.

The departures, especially of nurses, have compounded major staffing shortages over the course of the pandemic. The situation has become acutely difficult these past few months, particularly in regions where the Delta variant has overwhelmed hospitals and caused new spikes in Covid cases among nursing home staffs and residents. ...

At Novant Health, a large hospital group based in North Carolina, 375 workers were suspended after not meeting the system’s vaccination deadline this month. Another 200 agreed to comply, increasing the vaccination rate to over 99 percent of its more than 35,000 employees, according to Novant. ...

At Trinity Health, one of the first major hospital chains to announce a vaccine mandate, the percentage of its vaccinated staff has increased from 75 percent to 94 percent, said the group, which operates in 22 states.

SSM Health, a Catholic hospital group based in St. Louis, also adopted a mandate but said that few of its workers had left because of its requirement.

Hospitals and nursing homes have raised concerns about their ability to find workers if they impose strict requirements. The situation may be worse in rural areas, where limited numbers of workers are available. But healthy vaccinated workers may also ease staffing shortages.

At Houston Methodist, where 150 employees left from a work force of about 26,000 people, the hospital said that there had been little lasting effect on its ability to hire people. And when Texas was hit with rising numbers of Covid cases over the summer, the hospital found that fewer of its workers were out sick.

“The mandate has not only protected our employees, but kept more of them at work during the pandemic,” a hospital spokeswoman said in an email.

ChristianaCare, a hospital group based in Wilmington, Del., said on Monday that it had fired 150 employees for not complying with its vaccine mandate. But the group emphasized that over the last month it had hired more than 200 employees, many of whom are more comfortable working where they knew their colleagues were vaccinated.

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